After having been on Pristiq 100mg for 6 months with moderate success, it has recently stopped working. After discussing options with my doctor, he suggested I try to switch to Duloxetine. He recommended I completely stop Pristiq, and immediately go to a full dose of 60mg of duloxteine, however, I know from past experience that this will cause bad withdrawal symptoms from Pristiq.

I was wondering whether it was possible to cross-taper duloxetine and pristiq, or in other words, take 50mg of pristiq along with 60mg of duloxetine for a period.

Are there any harmful effects?