I current take Effexor (75 mg) and Wellbutrin (150mg). I have been taking the Effexor at night for about 6 months now, and recently (about 4 months ago) Wellbutrin was added. They said to take it in the morning but I don't wake up very early as I work late. I began taking it at night with my Effexor, there was no change in mood when I would take them separately nor together. Does the time in which I take it matter? It doesn't cause me to stay up later but I do think I've been oversleeping quite a bit. Otherwise there has been no shift in mood and I feel the same as before I took both medications.