I do not want a medication that causes weight gain.
If it is regular clinical major depression or dysthymia (rather than bipolar disorder) SSRI's (Selective Serotonin Re-uptake Inhibitors) and SNRI's (Serotonin Norepinephrine Re-uptake inhibitors) are usually the first medications used and are generally well tolerated and effective. They have a variety of side effects but there is no way to predict which you will get if any. The advantage is if one does not agree with you, you can try a different one.
Then there are the cyclic anti depressants all of which list weight gain as a potential side effect (which I guess means you would not even consider these) and lastly, as these have the most significant side effects are the MAOI's (Monoamine Oxidase Inhibitors) which involve dietary restrictions and/or modifications to avoid toxic side effects.
Bipolar disorder requires quite different management to other types of depression and I won't address that here.
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