How can I stop taking so many meds? I take so many prescription drugs that the side-effects are becoming worse than the conditions. I have severe depression since 1988, been hospitialized 3 times. I have anxiety disorder, OCD, Fibromyalgia, Hypothyroidism, high cholesterol, plantar fascilitis, acid reflux, and asthma. I have tried to change from Effexor because of it's many side effects and ended up in the hospital. I take Effexor 75 mg 3 a day, Klonopin 1 mg 2 a day, Xanax 1 mg 1 a day, two meds for cholesterol, Naproxen for pain from Fibro and Plantar Fascilitis, use an enhaler for the asthma, Endocet for the really bad days with the Fibro. so I don't take it everyday. Prilosec for the reflux, and a hormone for menupause due to a complete hysterectomy. I have gained so much weight, I'm only 5'2 and have gained almost 100 pounds over a five year period. I am no longer able to work, but I stay busy. I try to exercise but with the foot problems and asthma it's really hard to do. Swimming is my best form of exercise. I have never really been depression free in years. I am able to cope though. I desperately want to stop some of these meds. I would like to wean off the Effexor although the thought of the withdrawals scare me to death. Also, I would like to get off the anxiety meds. Maybe just stay on Klonopin and give up Xanax. I guess my my question would be, what is everyone's opinion on this? I know I will have my dr. involved and will it do any good to get off Effexor just to change to another anti-depressant? I don't think the others, and I've been on a lot of them, have as many side effects as Effexor, but also, Effexor has helped longer than the others. Such a mess, I hate all these drugs.