Yes there is, it is Moderate: Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Alprazolam with food it is also Moderate.
Interactions between your selected drugs
alprazolam ↔ trazodone
Applies to: Xanax (alprazolam), trazodone
Using ALPRAZolam together with traZODone may increase side effects such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience some impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with these medications. Avoid driving or operating hazardous machinery until you know how the medications affect you. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
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Other drugs that your selected drugs interact with
trazodone interacts with more than 400 other drugs.
Xanax (alprazolam) interacts with more than 300 other drugs.
Interactions between your selected drugs and food
alprazolam ↔ food
Applies to: Xanax (alprazolam)
Grapefruit and grapefruit juice may interact with ALPRAZolam and lead to potentially dangerous side effects. Discuss the use of grapefruit products with your doctor. Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor. Do not drink alcohol while taking ALPRAZolam. This medication can increase the effects of alcohol. You may feel more drowsy, dizzy, or tired if you take ALPRAZolam with alcohol.
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