Im currently taking Opana ER 15mg 3x a day with oxycodone 10mg 4x a day. My dr just switched my opana to exalgo er 16mg 1x a day plus my usual oxycodone. Is this going to be a big difference or will it be the same? Not quite sure what the difference is. She also mentioned oxycontin... but i dont know which would work better. Please... if you can help all advise is appreciated..thanks