i have been using minoderm for a long term because if u have been keeping using it the acne does not come up on my face but when i stopped it after one week acne start again with worse condition all over the face and feel pain and itching.(i have reaction like skin discolouration lips swelling diarrhea )_ since last 3 years i have not been using any tablet to eat just a cream duac gel ... but it stops working as well now doctor advised me to use doxycycline 100mg twice a day per week and after that doxycycline 50mg per day for two month. now i scared again about the reaction i don't want to use this medicine again for long time