The hand and foot syndrome I think I am learning more about and believe that the cold wraps during the chemo admn and after may be helpful to prevent access of chemo to pals and soles. I read in another blog that Rx Decadron 10 mg during infusion accompanied by Dexamethsaone 4mg tab, 2 x a day the day before, of and after, significant reduces this HFS. Anyone have experience with this or other suggestions?