I have only been taking Seroquel XR 50mg for 8 days and as far as I can tell it seems to be helping some. I have taken numerous SSRI drugs in the past and had negative results with every one I tried. I have noticed the Seroquel seems to make me feel a bit irritable at times but the benefit out ways the side effect. At first start of the medication, it made me very sleepy but now it does not put me to sleep. I feel like my dosage should be increased and possibly changed from to Seroquel rather than Seroquel XR as I feel the irritability only happens in the mornings from the hangover feeling of the XR. - FemaleSeekingAdvice