... My girlfriend is started taking Zonisamide about 7-8 months ago, she was previously on Depakote. She has not had a seizure in about 3 years and, physically, she feels much better on the Zonisamide. She has lost the weight that was gained while she was on Depakote and her constant stomach pains have disappeared. I however have noticed a change in her personality. She is irritable and angers easily. She has slowed cognitively and become very argumentative. She does not want to change medications again because she feels alot better, physically, on the Zonisamide. I am wondering if anyone else has experienced these side effects and how you handled it