Yes. This from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213250/
"... Dental Implications for Patients Medicated with Beta-blockers
Patients medicated with nonselective beta-blockers have a significant risk for acute hypertensive episodes if they receive vasopressors contained in local anesthetics, ie, epinephrine or levonordefrin. While treating patients medicated with nonselective beta-blockers, it is wise to record blood pressure and heart rate before administering local anesthetic-vasopressor formulations, then reassess those parameters 3–5 minutes after each cartridge is administered before giving another."
Metoprolol (toprol) is a selective beta-blocker so the risk for the above to happen is less.
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