as both rabeprazole and ranitidine decrease gastric acidity, they may affect absorption of drugs which require acidic medium for absorption, some of the anti tubercular drugs such as rifampicin, isoniazid and ethionamide may require acidic medium for absorption and thus may not get absorbed properly?
There appears to be no known significant interaction between rabeprazole and ranitidine with the antituberculosis drugs.
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