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Does plaquenil have a negative effect on metoporol?

Responses (1)

Rajive Goel 8 Jul 2010

After checking the meds on the Interactions Checker this was reported:

Applies to: metoprolol, Plaquenil (hydroxychloroquine)

Hydroxychloroquine may increase serum levels of metoprolol. The proposed mechanism is inhibition of CYP450 2D6 hepatic metabolism by hydroxychloroquine. In a randomized, double-blind, crossover study, seven healthy subjects with CYP450 2D6 extensive metabolizer phenotypes took 400 mg hydroxychloroquine or placebo twice daily for 8 days, and 100 mg metoprolol orally on the ninth day. Average metoprolol AUC increased by 65% and maximum plasma concentrations increased by 72%. No adverse effects were reported and the clinical significance is unknown. Clinicians should be aware of the possibility of an interaction if adverse beta-blocker effects occur.

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Please talk to your doc/pharmacist who prescribed the meds as meds react differently with different people taking them, hope this helps? free discount card

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