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Does lisinopril have a bad interaction with methadone?

Responses (1)

Rajive Goel 19 Jun 2010

Yes they need to be monitored, checked on the Interactions Checker this was found:

methadone ↔ lisinopril
Applies to: methadone, lisinopril

MONITOR: Many psychotherapeutic and CNS-active agents (e.g., anxiolytics, sedatives, hypnotics, antidepressants, antipsychotics, opioids, alcohol, muscle relaxants) exhibit hypotensive effects, especially during initiation of therapy and dose escalation. Coadministration with antihypertensive agents, in particular vasodilators and alpha-blockers, may result in additive effects on blood pressure and orthostasis.

MANAGEMENT: Caution is advised during coadministration of these agents. Close monitoring for development of hypotension is recommended. Patients should be advised to avoid rising abruptly from a sitting or recumbent position and to notify their physician if they experience dizziness, lightheadedness, syncope, orthostasis, or tachycardia.

Read more: https://www.drugs.com/interactions-check.php?drug_list=1476-0,1578-0#ixzz0rGcQz3MA

Hope this helps, however you could also check it with your doc/pharmacist.

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