Hello Friends, This is Ruth. I have a new email address. Have missed you guys. I have been down in my back and have felt awful. Has anyone experienced Opana ER wearing off before time of taking it again. I am on 40mg and take it twice a day and it wears off and if I take it sooner I can't sleep due to pain. If I don't take it sooner I am in alot of pain. The doctor won't let me take it three times a day until my appointment and I have just been miserable. Sorry about the typing. Arthritus in my hands is bad tonight. Love to all. Ruth