I don't know of anyone who has used Simponi so can't really comment, and none of the reviews say anything about lowered mood either.
There is no information about it under the known side effects of Simponi. I would suggest that you let your doctor know of your symptoms.
- Simponi Information for Consumers
- Simponi Information for Healthcare Professionals (includes dosage details)
- Side Effects of Simponi (detailed)
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