One reason for taking the VERY expensive Procardia XL is that w/ the osmotic delivery system, I can take it w/ water on an empty stomach OR w/ a meal, together w/ other meds. & supps. (vits. mins. & herbs). And, if I have a drink after dinner, its still OK. There aren't enough hours in the day to take each of my meds & supps separately on an empty stomach.