I am now taking depakote er 500mg in the day time and 500mg at bed time.Total dose is now 1000mg.I was on 500mg for the last 10 months.1000mg daily controls my aggression a lot.I am only worried about the intestinal damage issues.Is there anyone who is feeling well on depakote er for long time? I used to take Lithium SR 800mg before that but it didn't work.How do you consider the valproate in terms of safety?