I have been taking enbrel for 11 years. I worked great for me until the last year when it gradually stopped working. I did the self injection 2X week. Over the last year the relief subsided 2 days after the shots and then when I took the next 3-4 days from the last it would take 24 hours for the relief to kick in, sometimes no relief. My doc said he wants me to take Humira but for some reason (irrational or not) I am terrified of changing meds. I had no side effects from Enbrel except some minor sinus irritation -not infections. I am worried I won't be so lucky with another medine. Any one out there been on Enbrel that long and then changed to Humira? I would love to hear how you did. Thanks!