I take 1mg Xanax as needed for anxiety. I have checked the drug interactions between Wellbutrin and Brintellix. Is it common and/or good/bad to be on two SSRI's at the same time. I started Brintellix 10 days ago, actually feel a lot better. I am not making excuses (as much) to get up and do stuff, like workout and run errands. I haven't had any side effects, no nausea, no itching. I don't have to take Xanax to sleep anymore. Sleep 8 hours and feel rested now. Just wondered if being on the two antidepressants, though, is the best thing?