Please, chronic pain sufferers, those dealing with severe pain, depression, anxiety, etc, those experienced in dosage schedules for narcotic pain medications, muscle relaxers, benzos, etc- how far apart these medications need to be taken from each other. I am asking for advice about when to take these medications due to the CNS/respiratory depressant effects they have. Here is a list of my current medications and their instructions: Pristiq 100 mg 1x daily, Clonazepam 0.5 mg 4x daily if needed, Baclofen 10 mg 3x daily, Hydrocodone-Acetaminophen 10/325 4x daily if needed, Promethazine 12.5 mg 4x daily if needed, and Morphine Sulfate ER 15 mg 2x daily. The Morphine was just added today for chronic pain, was told to take it twice daily and the Norco as needed for breakthrough pain. I had been taking the Pristiq, Norco, and Baclofen first thing in the morning, followed by Clonazepam if I am anxious, and Promethazine if I am nauseous. I take the Norco every 4-6 hours, the Baclofen every 6 hours. Now that I will be taking Morphine in the a.m with the Pristiq and Baclofen, I was wondering how long I would need to wait before I could take a Norco if necessary. And 15 mg of Morphine Sulfate ER 2x daily, is 8 hours a part ok, or does it have to be 12 hours? The time btwn the Norco and Morphine are my biggest concern, but I have the Baclofen, Clonazepam, and Promethazine also in the mix. I just don't want to have CNS problems where I can't think, hypotension & dizziness where I have to be sitting/laying down or I'll pass out, and drowsiness where I have to sleep except for at bedtime. I also don't want to have breathing problems. I have mild Asthma, usually brought on by allergies in which case I take benadryl but only if I haven't had to take the Promethazine because they are in the same drug class. So... if anyone could help me with my medication schedule I would really appreciate it. I take my first meds as early as 7 am or as late as 10 am depending on my morning, and my last meds as early as 8-9 pm or as late as 11pm-12 depending on my night. Thank you in advance! I am seeking genuine advice from persons that support the use of narcotic prescription medication for pain mgmt and would appreciate it if people who are against the use of narcotic pain medication to refrain from responding. I've been attacked for questions regarding narcotic pain medication by people who seem to think they have the right to criticize me because they have "survived cancer or other debilitating illnesses without using narcotic pain medications... " This is not about your achievements... Sorry. Thank you for the understanding.