I had been taking Bicalutamide along with Goserelin since last September for metastatic prostate cancer but was switched to Flutamide in April after my PSA rose to ~7. My PSA dropped to ~.15 within a month after I started Flutamide. In the last couple of weeks, since late July, I have had increasing incidence and intensity of "stomach" irritation/inflamation when I take Flutamide. I have assumed that it's stomach irritation because Pantoprazole (40 mg twice a day) seems to help somewhat.