Yes, sertraline (Zoloft) and diphenhydramine HCl (Benadryl) as a sleep aid are fine together and using diphenhydramine. Avoid using OTC sleep aids with diphenhydramine that also contain acetaminophen, ibuprofen, or any other drugs unless you are experiencing pain that is contributing to your insomnia. Generic diphenhydramine is less expensive and contains what you want and only that. You can take up to 50mg, but keeping it to 25mg is always best if possible.
Also, try to use it sparingly. You can lose the drowsy, sleep aid effect if used too frequently.
Is your Zoloft causing insomnia? If so, what time of day are you taking it at? If at night, I suggest switching to taking it in the morning. Some people get a boost of energy from it, others become drowsy.
If your insomnia continues, see your doctor for other prescription alternatives.
(If you're wondering, my knowledge/information comes from both being a licensed pharmacist and prior to that, personal experience.)
Hi, great answer above! Just wanted to add, that taking the 2 together can increase the feelings of dizziness & drowsiness, so be careful driving, etc the next morning
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