I've been of 160 mg a day for about two years and lost over 50 pounds. Im really thin!! I've haven't had much of an appetite and even when I eat a lot, the weight still dropped. Apparently, I'm not being consistent with my eating habits. Early on, the doctor attributed the loss to a natural change in my metabolism from eating healthy. Now, I've simply lost the desire to eat, even when hungry. I can't believe after all this time I'm just now considering the possibility it's the Diovan. I'll be seeing my doctor ASAP.