Here is the drug interaction information. Be sure you read it carefully to avoid problems you may not know about.
Interactions between your selected drugs
diltiazem ↔ prednisone
Applies to: diltiazem, prednisone
PredniSONE may reduce the effects of diltiazem in lowering blood pressure. The interaction is most likely to occur when predniSONE is used for more than a week, since prolonged use can cause sodium and water retention. Let your doctor know if you experience sudden, unexplained weight gain or swelling of the hands, ankles, or feet. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
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diltiazem ↔ rivaroxaban
Applies to: diltiazem, Xarelto (rivaroxaban)
If you have kidney disease, you should talk to your doctor before using rivaroxaban together with diltiazem. Combining these medications can significantly increase the blood levels of rivaroxaban and increase the risk of serious or life-threatening bleeding complications. If treatment with the combination is required, you may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Call your doctor promptly if you experience any unusual bleeding or bruising, swelling, vomiting, blood in your urine or stools, headache, dizziness, or weakness during treatment with these medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
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No other interactions were found between your selected drugs.
Note: this does not necessarily mean no interactions exist. ALWAYS consult with your doctor or pharmacist.
Other drugs that your selected drugs interact with
diltiazem interacts with more than 500 other drugs.
prednisone interacts with more than 400 other drugs.
Xarelto (rivaroxaban) interacts with more than 200 other drugs.
Interactions between your selected drugs and food
diltiazem ↔ food
Applies to: diltiazem
Alcohol can lower your blood pressure and add to the effects of diltiazem. You may experience dizziness, lightheadedness, fainting, or a rapid heartbeat if you drink alcohol with diltiazem, especially when you first start taking the medication or just after a dose increase. Grapefruit juice may also increase the effects of diltiazem in some people by increasing its levels in the blood. You may want to limit alcohol intake and avoid excessive consumption of grapefruit and grapefruit juice during treatment with diltiazem. However, if you have been regularly consuming grapefruit or grapefruit juice with diltiazem, do not alter the amounts of these products in your diet without first talking to your doctor or other healthcare professional. Contact your doctor if your condition changes or you experience increased side effects of diltiazem such as headache, irregular heartbeat, swelling, unexplained weight gain, or chest pain. Orange juice is not expected to interact.
I take prednisone in the morning with breakfast. Fifty should be split into 25 for am and 25 for PM. This causes less of a reaction of flushing, rapid pulse, and an increase for some people in anxiety. But always with food. At fifty it will keep you awake so at night your sleep may be disturbed.
That breathing difficulty I get from time to time as well. I have ILD, or pulmonary fibrosis. I call it a catch breath. It happens spontaneously. It comes and goes. If under stress it seems more frequent to me. My Pulmonologist says it is normal and not to worry. I am on oxygen as well. However, since you have related heart problems,,it is best to call,your cardiologist and talk with your nurse. They may have to change the dosing of your medications a bit. Prednisone speeds the heart, and you are taking something to slow it. That is the conflict that concerns me more, don't worry about breathing unless you have a pneumonia brewing. Get your lungs listened to right away. No need for bigger problems. The body breathes automatically. I have found that I may hold my breath without realizing it. Perhaps you do as well. If you have a home nurse through Medicare, call right away and get checked. I have palliative care and many a trip to the ER Has been
Avoided by the nurse coming.
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