just started taking diltiazem to slow my heart down,and i asked the chemist if he could check to make sure i could take diazapam,and he said it was ok,but i like to make sure,Thanl you Rbyn
Applies to: diltiazem, diazepam
MONITOR: Coadministration with diltiazem may increase the plasma concentrations of drugs that are substrates of the CYP450 3A4 isoenzyme. The mechanism is decreased clearance due to inhibition of CYP450 3A4 activity by diltiazem.
MANAGEMENT: Caution is advised if diltiazem must be used concomitantly with medications that undergo metabolism by CYP450 3A4, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever diltiazem is added to or withdrawn from therapy.
Please seek more info by taking a second opinion, take care!
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