I have a blood cancer called, "Large Granular Lymphocyte Luekemia," which makes my body hurt often, due to lack of oxygen and red blood in my body. I also have Lumbar Facet Disease in my lower back. My pain doctor has me on 900 mg once a day of Gabapentin (Neuronin) for the back pain, Exalgo Extended Release 8mg twice a day and Hydromorphone 4 to 8 mg every 6 to 8 hours for breakthrough pain (can take up to 8 of the 4 mg pills). I am not getting much relief from the Hydromorphone (Dilaudid) anymore and am wondering if I have developed a tolerance. If I have, what is a good medicine to take the place of the Dilaudid and actually work? Percoset 15mg doesn't seem to help at all! I was told it was the strongest medicine available. I don't want to be a druggie. :(