I've been on the fentanyl 50mcg patch along with 3 7.5/375mg Hydrocodones per day for abdominal pain for a while, and my tolerance has pretty much skyrocketted (I was on strong opiates for several years a while back due to almost 10 abdominal surgeries). The last visit with my pain Dr, he said we might try switching medications to ones that'll use different receptors. My question is, what kind of meds would that encompass? Or, what would a doctor prescribe to someone who has huge tolerance to synthetic opiates?
dear Sal, hope you don't mind I shortened your screen name. Your dr. Might also be talking about the MU receptors in the brain, those are formed when rx opiates are used for long periods of time, they are the reason you build a tolerance, the more MU receptors, the higher the tolerance. If that is the case, some form of buprenorphine might be used. It comes in a patch, known as Butrans, in a pill or film form called suboxone or subutex. Ask your dr if he/she is talking about MU receptors. Your stomach also has opiate receptors and MU receptors, not just the brain, so this is another possible thing your dr may have been referring too. Hope this helps. Patti
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