I have been on 100 mg of Zoloft for awhile now. It has eased my depression but I still suffer. I have major depressive disorder, generalized anxiety disorder, PTSD, and panic disorder. I also have been on Xanax for 8 years was taking 5 mg a day and anxiety went up again and panic attacks came back recently. I have started titrating off Xanax now i am taking 4. I also take 150 mg of trazodone at night to sleep. Although it works well I have narrow angle glaucoma now. I was thinking of talking with my doctor about switching to Lexapro because it says it helps with both depression and anxiety. I am frustrated at this point and feel like I need to clear the slate at this point and start a new one.