So I've been prescribed different version of hydrocodone, usually Watson 540 or Watson 853. My question is the only difference I see between these 2 are the amounts of acetaminophen but how come the 540's seem to make me feel better than the 853? It seems like there are a lot of very similar pills out there like Vicodin that also show the same ingredients of these pills. What's the difference in all of these?
12 Oct 2011
I looked them up to make sure about this. But you are right, the only real difference is the amount of Tylenol, or acetaminophen in them. If you mean you feel better in terms of pain relief, then it's coming from the extra acetaminophen. For some reason acetaminophen and opiates amplify each other's pain relieving properties.
If you mean you feel better emotionally with one of them, then you are one of the few people who is hypersensitive to small changes in a drugs make up. I'm like that. Be prepared to be called crazy by docs and pharmacists all your life. And I'm not just hypersensitive to drugs like opiates, I'm also hypersensitive to many other drugs too, such as some of the meds used for HBP. One of my HBP meds effects me differently when the pharmacy changes the brand on me. This causes quite a problem since I'm talking about my heart here. I noticed the 2 Watson pills you're referring to are different colors. Maybe the dye is effecting you. Or more likely the Hydrocodone is being manufactured in different labs, and minute differences in the chemical make up of the drug are making you feel different. The large majority of people do not feel such differences, but some of us do.
The drug companies have a vested interest in having us believe all drugs are made equally. But the sad truth is they are not. I suppose a top notch chemist would know why this is, but other than a chemist, I don't think any of us can say why this happens. But it does, and now that you know you're one of the few people who feel the differences, try to always get the pill that agrees with your system best.
- Acetaminophen Drug Information
- Acetaminophen / Hydrocodone Drug Information
- Hydrocodone Drug Information
Search for questions
Still looking for answers? Try searching for what you seek or ask your own question.
I have two different Prescriptions one tablet says Watson 853 and the other says M363, when looking them up one says Acetaminophen Hydrcodone and the ...
2 answers • 13 Nov 2009
1 answer • 30 May 2010
1 answer • 26 Feb 2013
... Why was this change made? And were there any other changes besides color?
1 answer • 4 Jul 2013
Acetaminophen/Hydrocodone - just to let everyone including Drugs.com know that the hydrocodone10's!?
... (Watson 853) are not yellow now. They changed them to white with the same (Watson 853 inprint), for some reason I think they work better being ...
2 answers • 5 Feb 2015