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What is the difference between Symdeko and Orkambi?

Answers (1)

Official Answer by Drugs.com 7 Mar 2018

Three main differences between Symdeko (tezacaftor/ivacaftor and ivacaftor) and Orkambi (ivacaftor and lumacaftor) are their ingredients, the age groups they treat, and their approved indications. Symdeko contains ivacaftor, a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator indicated for the treatment of cystic fibrosis. Symdeko is used in patients 12 years and older who have two copies of the F508del mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene or who have at least one mutation that is responsive to tezacaftor and ivacaftor. Orkambi is approved for use in patients 6 years and older with two copies of the F508del mutation in their CFTR gene. Patients with two copies of the F508del mutation in their CFTR gene accounts for about 50% of all CF cases in the U.S. Ivacaftor (Kalydeco) is already FDA-approved to treat a smaller subset of CF patients age 2 years and older with only one mutation in the CFTR gene that is responsive to ivacaftor. Appropriate patients may also be transitioned from Kalydeco or Orkambi to Symdeko. Symdeko, Orkambi and Kalydeco are all manufactured by Vertex Pharmaceuticals.

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