I had a bad reaction to Prozac many years ago. I was told by my doc that I cannot tolerate ssri's. I was prescribed Cymbalta yesterday (snri) and was wondering what the difference between the drug classes was?
This question has also been asked and answered here: What's the difference between SSRI's and SNRI's?
Selective Serotonin Reuptake Inhibitor (SSRI)
Of the three neurotransmitters, SSRI's operate on serotonin. The body naturally decreases serotonin. SSRI's "inhibit" (slow or stop) this "re-uptake" (re-absorption) process.
Serotonin-norepinephrine Reuptake Inhibitor (SNRI)
SNRI's act on two of the neurotransmitters, serotonin and norepinephrine. Like the SSRI, the SNRI also affects the body's "re-uptake", of serotonin. In addition, SNRI's decrease the re-uptake of the second neurotransmitter, norepinephrine.
SSRI or SNRI?
Serotonin is thought to be the "mood" neurotransmitter. Norepinephrine is believed to be involved with "energy and alertness." Because SNRI's act on norepinephrine, in addition to serotonin, some believe these are more effective in treating depression, although individual patients respond differently to medication, and some feel the side effects of SNRIs are worse than those of SSRIs.
What was the reaction you to had to prozac? It may have just been prozac you can't tolerate not all ssris, how he could tell you that if all you've taken was prozac is beyond me.
masso416t9 was right on..but to elaborate further..for Effexor..it is like three drugs in one in low doses..affects the reuptake of serontonin like an SSRi only works as an SNRi or whatever they call them now at doses about 150mg and affects the reuptake of dopamine at still higher doses..so apparently, and in my experience a low dose of Effexor is useful for generalized and social anxiety, and panic attacks..higher doses for depression
Search for questions
Still looking for answers? Try searching for what you seek or ask your own question.
Updated 4 Jan 2017 • 7 answers
Updated 28 May 2016 • 5 answers
Updated 2 Jul 2018 • 3 answers
Updated 5 days ago • 2 answers
Updated 16 Jan 2019 • 5 answers