For over year taking metformin 500 mg am and pm with meals. Diarrhea strikes unexpectedly unrelated to when I've eaten. Recently I've had terrible episodes when not near bathroom... one in Bed Bath and Beyond. Yes, I had initial difficulties with adjusting to this med and things settled a wee bit but now I'm afraid to go out because it is so unpredictable. Planning a vacation to beach with no bathroom facilities near and anxious... ordered adult swim diaper finally as a precaution. Wondering after reading other comments if I should stop taking while on vacation with family. Only other medicines I use are valsartan for blood pressure and Alvesco and Combivent Respimat for asthma.