My neurologist just prescribed Diamox for my severe menstrual migraines. I was told to take 250 mg a day, starting right before my cycle, and to continue to take this dose until the end of my cycle, each month. Has anyone heard of this treatment route, or know why Diamox would help alleviate my symptoms? I researched the drug, and don't see much evidence that it actually helps with this type of headache. I also saw that it can cause fatigue and muscle weakness, both of which are a major problem already during my cycles, so I am a bit concerned.