I was recently diagnosed with hashimotos... tsh 2.13, peroxidase antibodies 400 free t4 11.1 ( ref range 9 to 19) free t3 4.7 (ref range 2.6 to 5.7). I have had symptoms of weight gain, fatigue and anxiety and depression that have not responded well to many different meds. My Dr started me on 75 mg synthroid. Can anyone help me understand my blood results? They don't seem like they are too bad!? Thanks!
Your TPOAb, or thyroid peroxidase antibodies level, is very elevated. Normal ranges vary, but are down near 1-34 IU or so. If you have subclinical hypothyroidism (not obvious by testing standards), a positive thyroid peroxidase ab result indicates a much higher risk of eventually developing overt hypothyroidism (obvious by testing standards). In Hashimoto's hypothyroidism, the TPOAb is elevated in 90-100% of cases. A testing standard includes the "feel" or palpation of your thyroid gland by the Dr. Possibly your Dr. felt a goiter, or enlarged thyroid, and paired with the TPOAb results, knew you needed to be treated for Hashimoto's. These are 2 clues that don't require all of your thyroid tests to be abnormal before you can be diagnosed. Your weight gain, fatigue, anxiety and depression are other clues.
TPO is an enzyme that converts T4 to T3. TPOAb is an antibody to TPO. This is an autoimmune reaction by your body. Antibodies are created to attack and protect your body from "invaders", or things that don't belong and could do you harm. Harmful bacteria and viruses are among the things antibodies attack. When antibodies turn against your thyroid gland, your body is mistakenly attacking itself... called an autoimmune response.
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