I can't really tell you when this set in, I can tell you I have no feeling below my knees. I guess When I got my Disability my mobility when to a standstill. I lost my license, so I don't drive. I used to get and go. I don't do that anymore. I am pretty much sedentary. I'm afraid to walk some places, problems with curbs up or down. There is a yellow safety plate at a place I frequent that I can't get past. I have seen a surgeon about the neuropathy, they gave me compression stockings and come back in 6 months. That was a year ago. I am an overweight, 47-year-old male. I suffer from 16 other conditions not including the pain I get. I have a medicine chest full of pills. I took them all once and woke up the next day like nothing happened.