I was diagnosed with Diabetes in 2004, since then I have been taking mostly Metformin 500 daily with various other medications. But in the year 2008 my sugar level shot up to 20 mmol/l and some time above and also my creatinine was 1.8. My Doctor Prescribed me Amaryl 2mg and stopped other diabetic medicines. latter he decreased the Dose to 1mg daily once,which I am continuing.