My depression does not include delusions, hallucinations, mania, hypomania, or any of the bipolar/ schizophrenic symptoms. I know it says it can be an add on therapy but why would someone with depression be prescribed that considering all of the side effects the drug causes? I’m asking for opinions only so please don’t be politically correct. I’m trying to see this through a different perspective since it does not have any logic from my perspective. I have read plenty of websites explaining it but it doesn’t seem logical to me.
Depression - Why do some psychiatrists prescribe atypical antipsychotics for MDD?
- 14 Jul 2018 by Fakingitperfectly
- 22 October 2018 (4 weeks ago)
- depression, mania, schizophrenia, bipolar disorder, major depressive disorder, hallucination, prescription, antipsychotic, symptom, psychiatry, therapy, antipsychotics, atypical antipsychotics
Good question! Don't really have a good answer other than that the few people who I know who received adjunct antipsychotics medication had depressive episodes so severe that they required hospitalization. Too, the doses of the antipsychotics medication were very small and were considered an adjunctive treatment in addition to a full dose of SSRI or SNRI. I'll be interested in hearing what others have to say.
All the best!
Hi, Faking! Most antidepressants (SSRI's) primarily affect the brain neurotransmitter serotonin which is partially responsible for mood... the SSNRI's also affect norepinephrine to a lesser degree. Antipsychotics directly affect dopamine receptor sites:
"A second generation of antipsychotics, commonly referred to as the atypical antipsychotics, block D2 receptors as well as a specific subtype of serotonin receptor, the 5HT2A receptor. It is believed that this combined action at D2 and 5HT2A receptors treats both the positive and the negative symptoms. "
In effect, the antipsychotic works in one way to reduce symptoms of depression, boostering mood, and by increasing the action of the antidepressant.
That being said, my MDD (treatment resistant) was almost completely alleviated by the addition of Abilify to my antidepressant. I've been taking both for almost five years with excellent results.
Best regards, Wildcat
I have learned that some ,medications have frequent side effects that can be used to the advantage of the patient with MDD. I have had MDD for over 30 years. No doctor, no medication is perfect. I am fortunate to have a great psychiatrist who explains everything to me. . If am feeling different or there is some unusual 'side effect' I am experiencing, I let her know. I also check drugs out on my own. If I am worried about any possible problem, I tell her. Unfortunately there is no perfect drug for everyone. It works differently on different people, hence putting one on the market with all those side effects. I was really bad off before my treatment. Sure it hasn't been perfect but it certainly saved my life. I don't know if this helps or not.
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