Which is better for depression nortriplyline or zoloft? Also, which one has less side effects?

They both have side effects and they are both decent. It all depends on the person which has the least side effects and works the best.

Hello hardworker17. My choice would be Nortriptyline/Pamelor. Side effects in my opinion are less. However for the drug to work effectively, blood levels are monitored unlike Zoloft. Regards pledge

As for which works best, it really depends on the person... If you've been on other antidepressants before, you can look at how they worked for you. Zoloft is an SSRI, so if you've tried other SSRIs (Prozac, Paxil, Celexa, Lexapro, Luvox) and they didn't work well for you, trying nortriptyline might be a good option.
As for side effects, again - depends on the person... Personally, I didn't like nortriptyline because I found it caused weight gain for me. Not everyone experiences the same side effects tho.

Good luck and take care!

- Hope316