... antidepressants.i take elavil and i was not benifiting as good as i hoped so i started on the sam-e and it seems like its making my antidepressant work better.i eas really suprised at how fast it worked it kicked in after abou two weeks and i can tell a major change in my moods,even my family has noticed.so anyway i just wanted to get some peoples opinions and to see if anyone else is dointhis