I started taking reyataz and epzicom 7 years ago and became very depressed right away. I took cymbalta for about 5 years which helped but had sexual side effects I did not like. Since stopping the cymbalta I have tried several other antidepressants with less success. I am curious if there are any other antiretroviral options that might have less depressive side effects? I hate to complain because I am grateful to have the options I have, but I am very depressed and it did seem to happen almost immediately after I started my HIV meds. Any thoughts or suggestions would be welcomed!