I'd like to hear from others who have had depression all their lives, I've tried numerous meds. Prozac worked well for about 6 yrs. Then stopped working. Now I take Effexor XR 225mg daily with fair results. I also take Lyrica 100mg in am and 50mg in pm. Depression is still a big issue but am fearful of adding more/another med because of the CFIDS and fibro. DR. suggested Cymbalta and possible Abilify. Have not been able to work for over a year now due mostly to CFIDS and fibro. No income. No insurance. Still depressed! Plus I just turned 50!! Life wasn't suppose to work this way but I guess it could be much worse!