Prolonged use of Depo-Provera may result in loss of significant bone mineral density, increasing the risk of osteoporosis. This risk is more likely for those who have been taking it for longer than two years, particularly when other risk factors for osteoporosis exist, such as family history and chronic alcohol and/or tobacco use. Although there are no studies to benefit its use, it is advised that all women on Depo-Provera get adequate calcium and Vitamin D (through diet and/or supplements) to help prevent osteoporosis.
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