I am on Lamictal and Wellbutrin for Bipolar 2 disorder but stopped Lexipro several months back. Although, I have much more energy, the irritability that the lexipro was good for is coming back. I'm wondering if Deplin instead of PoDiaPN would help with this. Any thoughts??
I doubt that the active ingredient in Deplin, l-methylfolate, would be helpful directly for irritability. A lot depends on whether the cause of the irritability is internal or external. L-methylfolate is used by the brain to help produce our neurotransmitters, like serotonin, dopamine, norepinephrine, and others. If your irritability is being caused by the lamotrigine or bupropion, it won't help because it is an enzyme, not a tranquillizer. L-methylfolate is available in 7 1/2 and 15 mg capsules, and is also available OTC. It is not cheap, but it has no side-effects and it won't interfere with anything you're taking because it's just used in the brain. IOW, it won't hurt you to try it. Your MD can get you free samples, if the two of you agree. I found a good diagram of how it works at www.methylpro.com, the company I get my methylfolate from.
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