It does not work anymore any going to switch to the new Opana ER 20 mg. Will I get any effect from the new drug because of Subutex's high affinity?
Thank you for your response balbanese. I just had back surgery about 6 weeks ago and I am still in nonstop back,hips,legs acute pain(sciatica too) I wake up every morning in excruciating pain and then it gets worked out. The only thing that works (very little) is Ibuprofen. That's like trying to kill a whale with a bee-bee gun! I have to get off the Subutex all it does is make me feel lethargic and no pain relief. In Post-Op I woke up screaming and wide awake with no pain relief! The nurses and doctors kept pumping me full of morphine and nothing. I felt everything! Then some anesthesiologist with a little knowledge of Subutex has the great idea of starting me on a Ketamine drip.
He had to bolus through my IV and he told me that it is a street drug too, similar to PCP? He filled up the syringe and seconds after I was injected I felt a very warm rush and then it progressed to insane amount of adrenaline. Then everything appeared to be red and I had to close my eyes and my heart was literally pounding out of my chest. The anesthesiologist saw my heart rate (170bpm) and ordered the nurses "Too Versed's." I slowly came down from my adrenaline high(I though I was going to die) and they started the drip and I really didn't feel the effects of the Ketamine. They told me it would help the painkillers to work. They did not, I was in Post-Op for 8 hours and no pain relief! It took around 38hrs before the morphine 10mg every our and 15mg of Oxycodone started to work a very little. I was to tortured for almost 2 days! I could not take the Subutex anymore and was sent home with Oxycontin 40mg 2x a day and Oxycodone 5mg to take 3 to 4 tablets every 4 hour as need. I have never taken that large amount of painkillers. They did work I felt better but I came to find out I have acute opiate tolerance? This sucks, I had enough medication for a month when my Post-Op Dr's appointment was. But only enough Oxycodone for 7days I made them last 12 and tried to get a refill because I still had break-through pain. The surgeon said he would no longer prescribe me any more opiates and I should get back on Subutex! And that was my only option. So I have been on it for about a month and need to switch to something else because for some reason the Subs. don't work anymore and I was prescribed the highest dose 32mg a day! I don't take that much, only about 8 to 16mg every other day to keep the withdrawal away. I need to Know If the new TimerRX opana 20mg 2x a day will work or do I need to be in withdrawal for it to work? Please help in so much pain!
Opiates such as morphine or oxycodone will not work when you have Subutex (buprenorphine) in your system. The buprenorphine blocks the receptor sites and keeps the other opiates from attaching to stop the pain. You can take the Opana but it won't work for 3 to 5 days until the Subutex has left the brain receptors. You don't need or want to go into withdrawals though so you'll have to take the Opana shortly after stopping the Subutex to prevent this.
Hey For help, you can start the opana, but it may be blocked for a few days and you can start it the night of your last subutex dose thqt morning, or wait 24 hours if you can. More opana or any opiate will not work while the subutex is wearing off, but as it wears off, the opana will work. Some people can feel the opiate relief earlier than 3 days, but tking more opiate to try to get it to work, will not make it work faster. Since you are on subutex, vs suboxone, it might wear off a bit quicker than suboxonr and allow the opiates to work. When or if you go into subutex withdrawal, that should be a sign the subutex is off the receptors and it should start working then. Here's hoping you get relief soon. Patti have you asked about a fentanyl patch and break thru meds. Fentanyl is time released patch and often this works for intense pain, along with short acting or immediate release opiates. I am so sorry you are in pain and not getting more relief.
Many drs see subutex use as a sign the person has had an opiate problem, and never stop to think the person may have been talked into it for pain, and not just to keep them out of opiate withdrawal. If you had been tapered slowly off of it, it may have reversed the opiate tolerance slowly, hard to say, since you couldn't and have a real reason now for your pain levels to be way up because of the recent surgery. Patti
I think that you need to ask your doctor about opioid rotation. I was on WAY high dose of meth, and I had major surgery, and I UNDERSTAND what you went through. They could NOT control the pain at all, and I kept asking them to KILL me. I couldn't bear the pain, my blood pressure was so high that they kept layering me in nitro patches, and I just wanted to die. Literally. They finally got the pain under control with an EXCELLENT pain doctor (too bad I was in a different state at the time, or I would have kept him). I had to have an epidural in me for two weeks, plus extra pain meds. It was a nightmare that I never want to have repeated.
What the pain doc did for me in two weeks was to slowly work the meth out of my system through the epidural and the opioid rotation. I will NEVER take meth again. Bad drug. He kept changing my pain meds every few days with a different narcotic at a lower dosage every three days. I never felt the pain come back, and actually through the rotation, I actually got more pain relief than I would have from the original meth that I was on. It's worth a try, especially if you suffering from so much pain. Best of luck!
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