and had a PE (likely starting from a DVT) in '01. I'm 41, active, healthy, and do NOT have any genetic thrombolytic factors. I am currently on combination therapy with Coumadin, Plavix, and Aspirin and will take Coumadin for life. I understand that each drug somehow acts differently to prevent clots, but I also know that combination therapy puts one at great risk for bleeding. Is there evidence supporting combination therapy vs. single medication therapy (Coumadin)?
Based on the information that you provided it appears that you have two different issues. Your doctor must believe that you have platelet issues along with your PE & DVT issue, or s(he) is being very cautious. I am assuming that you have gone to a Hematologist since you state that you do not have any genetic blood disorders. If you want to get off of the Plavix I would suggest that you go to a Cardiologist and have them do a stress echo test. If that cannot be accomplished then it will be suggest that you have a heart catheterization which will clearly show if you have platelet blockage and the continued need for Plavix. Since they are two different issues Coumadin is not indication or approved as it has no effect on the platelet modality. Do you wear pressure socks when you travel long distances in any form of transportation?
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