most of my patients have being asking me about it but it seems they are always not convinced about what i tell them.
There are 3 alcohol/food/lifestyle interactions with ciprofloxacin,
this is 1 of them:
ADJUST DOSING INTERVAL: Concurrent ingestion of dairy products (milk, yogurt) or calcium-fortified foods (i.e., cereal, orange juice) may decrease the activity of certain oral fluoroquinolone antibiotics. The mechanism is chelation of calcium and the quinolone, resulting in decreased bioavailability. In the case of orange juice, inhibition of intestinal transport mechanisms (P-glycoprotein or organic anion-transporting polypeptides) by flavones may also be involved. One study reported an average 41% decrease in maximum plasma concentrations and a 38% decrease in AUC when ciprofloxacin was given with calcium-fortified orange juice instead of water.
MANAGEMENT: Dairy products or calcium-fortified foods should be ingested at least 2 hours after or 6 hours before fluoroquinolone administration.
Click on the link to read about the other 2 interactions, and also drug and disease interactions:
- Ciprofloxacin Information for Consumers
- Ciprofloxacin Information for Healthcare Professionals (includes dosage details)
- Side Effects of Ciprofloxacin (detailed)
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