The side affects seem to be going away. I was on zoloft 100mg for approx, 3-4 months and it did nothing for me. I am currently on 50 mg of zoloft and 30 mg of duloxetine. My doctor did not want to take me totally off the zoloft until the duloxetine had a change to get into my system. Like I said I'm at day 20 and I have days where I have a lot of energy and a positive attitude, but I also have days where I have no motivation or feel like getting out of bed. Has anyone experienced these highs and lows, and if so how long until you truly felt better and evened out? I think I forgot to mention that I take it for anxiety and depression. This is my first time posting anything and also my first time on anti-depressants, so I'm not sure what to expect. I just want to feel good about myself and happy to wake up in the morning, and not edgy and wanting to take someones head off,. I'm beginning to wonder if I will ever experience that. I go back to see my doctor on the 27th of this month.