... depression got better. Over the last couple of months, I have been experiencing extreme fatigue, so I cut my dose in half (from 120 to 60mg) and started taking it at night, which didn't improve my energy levels. I've had many tests done as well as blood work, and the drs can't find any reason for this. Has anyone suffered from fatigue while on Cymbalta despite not having this reaction for some time in the beginning? I'm so scared I'm going to feel this tired forever