I love coffee & drink about 10 cups a day. Is there any known interactions between cymbalta and coffee?
The interaction between caffeine and Cymbalta are as follows:
caffeine ↔ duloxetine
Applies to: caffeine, Cymbalta (duloxetine)caffeine ↔ duloxetine
MONITOR: Coadministration with inhibitors of CYP450 1A2 may increase the plasma concentrations of duloxetine, which is a substrate of the isoenzyme. In 14 male study subjects, coadministration with 100 mg fluvoxamine, a potent CYP450 1A2 inhibitor, resulted in a 2.5-fold increase in duloxetine peak plasma concentration (Cmax), a nearly 6-fold increase in duloxetine systemic exposure (AUC), and an approximately 3-fold increase in duloxetine half-life. The interaction has not been studied with less potent CYP450 1A2 inhibitors such as mexiletine, propafenone, and zileuton. Theoretically, high plasma levels of duloxetine may increase the risk of serious adverse effects such as hypertension, hypertensive crisis, increased heart rate, orthostatic hypotension, syncope, and serotonin syndrome. Serotonin syndrome is a rare but serious and potentially fatal condition thought to result from hyperstimulation of brainstem 5-HT1A and 2A receptors. Symptoms may include mental status changes such as irritability, altered consciousness, confusion, hallucinations, and coma; autonomic dysfunction such as tachycardia, hyperthermia, diaphoresis, shivering, blood pressure lability, and mydriasis; neuromuscular abnormalities such as hyperreflexia, myoclonus, tremor, and ataxia; and gastrointestinal symptoms such as abdominal cramping, nausea, vomiting, and diarrhea.
MANAGEMENT: Caution is advised if duloxetine is used in combination with CYP450 1A2 inhibitors. Pharmacologic response to duloxetine should be monitored more closely whenever a CYP450 1A2 inhibitor is added to or withdrawn from therapy, and the dosage adjusted as necessary.
I know that is alot to read and understand but the bottom line is you may need to reduce your caffeine intake so to avoid hypertension and increased heart rate problems.
Hello ciaran. I couldn't help but chuckle and smile, because I love my coffee. I mentioned earlier on, in another comment, that I was on cymbata for almost a year. Most times on 60mg and I believe for oh, two months on 90mg. I stopped it around December of last year. And have just restarted it again last week. For the time I was cymbalta free, versus being on it, I drank and still do, easily, 7 to eight (mugs) of coffee. Thats a lot of java. To this day, my behaviour was the same as far reactions/effects are. But, we all react differently, to our meds, and our beverages and foods. So, if you were or are planning to go on the cymbalta, I suggest a little bit caution, with the coffee. The only time, throughout my life, in regards to coffee and medications, was when I was on parnate. No Coffee, no caffine. But, I no longer take parnate. And I wish you well ciaran, regardless of what medication you might be taking or plan to take, best wishes to you and everyone, hope that your days are only good ones,
- Cymbalta Information for Consumers
- Cymbalta Information for Healthcare Professionals (includes dosage details)
- Side Effects of Cymbalta (detailed)
Search for questions
Still looking for answers? Try searching for what you seek or ask your own question.
Posted 11 Sep 2010 • 1 answer
Posted 17 Oct 2012 • 3 answers
Posted 9 Apr 2013 • 1 answer
I am not sure we are using the drug interaction section correctly. Can you give me the steps?(prof)?
Posted 7 Jan 2014 • 2 answers
Posted 4 Sep 2016 • 1 answer